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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor of PI3K in cervicalcancer cells and the expression of FLICE-like inhibitory protein (c-FLIP) .Human cervical cancer HeLa cells were used in this experiment and cultured.cancer cells.Moreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical lesions have been regarded as the common and frequently occurring diseases in China.Recently, the morbidity and youth tendency of cervical cancer have gradually increased.Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseasesThe well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviorsintraepithelial neoplasia (CIN), and cervical cancer.

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelialneoplasia     cervical cancer    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 459-462 doi: 10.1007/s11684-009-0084-8

Abstract: The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in womenunder 30 years old with cervical intraepithelial neoplasia (CIN) or cervical cancer, in order to providea basis for cervical cancer prevention and treatment.colposcopy for screening CIN or cervical cancer.The prevalence of HPV and cervical precancerous lesions or cervical cancer was evaluated in different

Keywords： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladder cancer, and the effect of anticancer BAK cells was studied.BAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cellsThe result of LDH release assay showed that the antitumor activity of BAK cells stimulated by RecombinantWe conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer than wild-type BCG

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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A new thinprep cytologic test of cervical cells and its application

Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 227-229 doi: 10.1007/s11684-009-0035-4

Abstract: test (TCT) for cervical cells.In one group, the TCT for cervical cells was applied (TCT group), and in the other group routine cervicalmedium so as to eliminate mucus, inflammatory cells and blood cells.the TCT was superior to the routine cervical smear.Meanwhile, in comparison to the routine cervical smear, the TCT for cervical cells has 5 advantages which

Keywords： thinprep cytologic test     cervical cells     Papanicolaou smear    

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Cervical cancer (CC) is the fourth most commonly diagnosed female malignancy and a leading cause of cancer-related

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract:

microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasisOn the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAscan function as tumor suppressors or oncogenes that target many cancer-related genes.on the biological behavior and mechanism of proliferation, migration, and invasion in the prostate cancerHence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145;

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervicalcancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervicalcancer having risk factors after surgery.adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervicalcancer having pathological risk factors.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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HPV prevalence and genotyping in the cervix of Chinese women

Shao-Ming WANG, Jing LI, You-Lin QIAO

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 259-263 doi: 10.1007/s11684-010-0095-5

Abstract: The role of human papillomavirus (HPV) as an etiologic factor of cervical cancer has been firmly establishedVaccination implies a promising future for cervical cancer prevention especially for countries with veryof most recent years, and aims to draw a definitive conclusion on HPV prevalence and genotyping in cervicalcancer and precancerous lesions in China from the aspect of study population, geographic areas and time

Keywords： human papillomavirus (HPV) genotyping     cervical cancer     precancerous lesions     Chinese women    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract:

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasisHowever, the molecular alterations that drive progression and metastasis of cervical cancer remain uncleartranscription factor, has been suggested as an oncogene because it is overexpressed in many types of humancancer.cancer.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Analysis of the results of cervical cancer screening for 49 384 rural women in Hetian District，Xinjiang

Wang Ying,Wang Xiaoli and Mi·Siriergeleng

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 96-98

Abstract:

To analysis the results of cervical cancer screening for rural womenThe research provided epidemical instigation of cervical cancer and clinic service for local women byThe prevalence rate of cervical cancer and precancerosis is 0.09 %，early diagnosis rate is 86.05 %.

Keywords： cervical cancer     Xinjiang     gynaecologicaldisease    

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relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervicalcancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: to evaluate the relationship between PDGF expression and stages and metastasis of cervical cancer.At the early stage of cervical cancer, BVD and LVD were significantly higher than in the controls (<The BVD and LVD in tissues in the surrounding areas of cervical cancer were significantly higher thanBVD and LVD were not associated with the differentiation and pathological stages of cervical cancer.of cervical cancer.

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract:

Many gene fusions have been recognized as important diagnostic and/or prognostic markers in human

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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Title Author Date Type Operation

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Journal Article

A new thinprep cytologic test of cervical cells and its application

Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU

Journal Article

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervicalcancer: a randomized, non-inferiority, multicenter trial

Journal Article

HPV prevalence and genotyping in the cervix of Chinese women

Shao-Ming WANG, Jing LI, You-Lin QIAO

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Analysis of the results of cervical cancer screening for 49 384 rural women in Hetian District，Xinjiang

Wang Ying,Wang Xiaoli and Mi·Siriergeleng

Journal Article

relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervicalcancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article